Metastasis Research Laboratory
The Metastasis Research Laboratory was founded in 1992 and is addressing several aspects of cancer development and progression mainly related to metabolism and biomarker discovery.
Research themes & scientific expertise
Metabolic Stress and Cancer (MSC)
Our team aims at understanding the importance and the impact of metabolic stress, mainly glycation, in the aggressiveness of cancer cells.
Mitochondrial Adaptation and Cancer (MAC)
Our team aims at deciphering the mechanisms leading to the mitochondrial adaptation in pancreas cancer. We focus our attention to the mitochondrial dynamics and to its functional fitness. Myoferlin was identified as a promising therapeutic target.
News
Publication in EMBO
Myoferlin: a promising target to reduce tumor fibrosis
A team led by Olivier Peulen (Metastasis Research Laboratory) has identified myoferlin as a promising target to weaken the tumor microenvironment in pancreatic cancer and potentially enhance treatment response.
PUBLICATION IN J EXP CLIN CANCER RES
New connection between tumor energy metabolism and epigenetic regulation
This study by Akeila Bellahcène's team (Metastasis Research Laboratory) characterized an epigenomic signature of methylglyoxal that effectively discriminates triple-negative breast cancer patients with poor survival.
Publication dans Redox Biology
Pharmacological targeting of myoferlin sensitizes pancreatic cancer cells to ferroptosis
The Metastasis Research Laboratory (O. Peulen and A. Bellahcène) provides new insight into the importance of myoferlin in pancreatic cancer. Its pharmacological targeting sensitizes PDAC cells to ferroptosis.
Last publication
Myoferlin protects colon cancer cells from p53-driven apoptosis
Olivier Peulen's group shows that myoferlin protects colon cancer cells from a p53-induced cell death. Multimodal chemotherapy, targeting myoferlin and restoring p53 activity, could be considered as relevant in patients with this cancer.
Metastasis Research Laboratory
Université de Liège, Quartier Hôpital
Institut de Pathologie B23, 4ème étage, Route 688
Avenue Hippocrate 13
B-4000 Liège (Sart-Tilman), Belgium
| (Metabolic Stress and Cancer) |
(Mitochondrial Adaptation and Cancer) |
|---|---|
| Co-directeur | Principal Investigator |
| a.bellahcene@uliege.be | olivier.peulen@uliege.be |
| +32 4 366 25 57 | +32 4 366 37 92 |
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